Ca2+-independent hypoxic vasorelaxation in porcine coronary artery
نویسندگان
چکیده
منابع مشابه
Enhanced b-receptor-mediated vasorelaxation in hypoxic porcine coronary artery
Fukuda, Satoru, Takashi Toriumi, Hui Xu, Hidenori Kinoshita, Hironobu Nishimaki, Seiichiro Kokubun, Naoshi Fujiwara, Hideyoshi Fujihara, and Koki Shimoji. Enhanced b-receptor-mediated vasorelaxation in hypoxic porcine coronary artery. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1447–H1452, 1999.—To investigate the b-adrenoceptor-mediated responses in hypoxic coronary arteries, we studied th...
متن کاملEnhanced β-receptor-mediated vasorelaxation in hypoxic porcine coronary artery.
To investigate the β-adrenoceptor-mediated responses in hypoxic coronary arteries, we studied the effect of isoproterenol (Iso) on isolated porcine coronary arteries contracted with endothelin-1 in media aerated with 0, 5, 7.5, and 95% O2. The concentration-response curve of Iso was significantly shifted to the left by hypoxia (0 and 5% O2). In oxygenated and hypoxic arteries, 3 × 10-8, 10-6, a...
متن کاملMechanisms of vasorelaxation induced by troglitazone, a novel antidiabetic drug, in the porcine coronary artery.
BACKGROUND Troglitazone (TRO), a novel antidiabetic drug, has been reported to decrease blood pressure and relax vascular strips. The mechanism of relaxation induced by TRO was determined in terms of Ca2+ signaling in smooth muscle cells. METHODS AND RESULTS Front-surface fluorometry and fura 2-loaded medial strips of porcine coronary artery were used to examine the effects of TRO on cytosoli...
متن کاملEndothelium-Independent Hypoxic Contraction Is Prevented Specifically by Nitroglycerin via Inhibition of Akt Kinase in Porcine Coronary Artery.
Objective. Hypoxia-induced sustained contraction of porcine coronary artery is endothelium-independent and mediated by PI3K/Akt/Rho kinase. Nitroglycerin (NTG) is a vasodilator used to treat angina pectoris and acute heart failure. The present study was to determine the role of NTG in hypoxia-induced endothelium-independent contraction and the underlying mechanism. Methods and Results. Organ ch...
متن کاملPorcine Coronary Artery
coronary artery contraction evoked by thromboxane A2 (TXA2) were studied in vitro. Ring preparations of porcine proximal coronary artery were suspended in a Magnus apparatus filled with Tyrode's solution at 370 C and aerated with 100%0 02, and the isometric tension of the contractions was measured. Insulin itself caused neither contraction nor relaxation. Insulin had no significant effect on th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2005
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2004.073692